Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Erythroblastosis, Fetal/diagnosis , Erythroblastosis, Fetal/epidemiology , Erythroblastosis, Fetal/pathology , Erythroblastosis, Fetal/prevention & control , Erythroblastosis, Fetal/therapy , Clinical Protocols , Prenatal Diagnosis/methods , gamma-Globins/administration & dosage , Rho(D) Immune Globulin , Incidence , Blood Group Incompatibility , Rh Isoimmunization , Blood Transfusion, IntrauterineABSTRACT
Se analizan los egresos y se presenta la morbilidad acaecida entre 1996 y 1997 en la Unidad de Neonatología del Hospital Clínico de la Universidad de Chile. La mortalidad se analiza en publicación aparte. Sobre un universo de 4827 partos producen 1231 egresos. La principal causa de egreso es el sindrome ictérico (40,2 por ciento) seguidos por hipoglicemia (9,8 por ciento), prematurez (8,8 por ciento), sindrome de dificultad respiratoria (5,4), enfermedad hemolítica (5,1 por ciento), infecciones neonatales (4,8 por ciento). La infección grave está presente en el 7,3 por ciento de los neonatos. El promedio general de días de estada es de 6,6 días. El 62,7 por ciento corresponde a RN de mas de 3000g de peso que evolucionan con una estada de 2,9 días promedio en contraste con el 8 por ciento de niños de menos de 1500g que tienen un promedio de 42,2 días. Se hace necesario una clasificación diagnóstica que tenga aplicación clínica y que sea fácilmente comprensible y comparable a otras casuísticas
Subject(s)
Humans , Infant, Newborn , Female , Pregnancy , Infant, Newborn, Diseases/epidemiology , Hospitals, Teaching/statistics & numerical data , Patient Admission/statistics & numerical data , Birth Weight , Chile/epidemiology , Delivery Rooms/statistics & numerical data , Erythroblastosis, Fetal/epidemiology , Gestational Age , Hypoglycemia/epidemiology , Infant, Premature , Insurance, Health/statistics & numerical data , Morbidity/trends , Respiratory Distress Syndrome, Newborn/epidemiology , Length of Stay/statistics & numerical dataABSTRACT
To determine the frequency of various blood group antibodies responsible for haemolytic disease of the new born [HDN]. DESIGN: A prospective study of all neonates and still born foetuses suspected to have haemolytic disease of the new born and their mothers. SUBJECTS: Neonates suspected to have HDN as per study criteria along with their mothers and mothers of still born foetuses with hydrops foetalis. METHODS: Pertinent serological tests, serum bilirubin estimation, haemoglobin estimation and reticulocyte count on neonate's blood samples and demonstration/titration of blood group specific antibodies in maternal blood samples. Six cases of HDN due to blood group antibodies were detected so far. Four were due to anti-D and all were of mild severity as per study criteria. Two cases were of severe haemolytic disease [hydrops foetalis]. Both were due to anti Kell. Both women had history of previous blood transfusion and abortions. Comprehensive antibody screening should be performed during antenatal period in women who have received blood transfusion and/or have history of un-explained abortions